Analyze Factorial Design - Weights
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Stat > DOE > Factorial > Analyze Factorial Design > Weights

You can specify weights for your model to perform weighted regression, which is a method to handle data with observations that have different variances. Store weights based on the variability in your response across repeats or replicates in Analyze Variability.  

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Do a weighted fit, using weights in: Enter a column that contains weights for your response. The column must be the same length as the design variables.